Genes, Lifestyle and Chance – Success or Failure!

by | Nov 28, 2017

Healthy aging and longevity in humans are modulated by a lucky combination of genetic and non-genetic factors such as diet and lifestyle.

Genetics, Lifestyle and Chance – the 3 legs of your health

Family studies demonstrated that about 25 % of the variation in human longevity is due to genetic factors. The search for genetic and molecular basis of aging has led to the identification of genes correlated with the maintenance of the cell as Dr. Shaklee said.   Its the basic metabolism which is the main genetic factor affecting the individual variation of the aging symptoms. In addition, studies on calorie restriction and on the variability of genes associated with nutrient-sensing signaling in foods, have shown that a precision diet and a genetically efficient metabolism of nutrients, can improve lifespan by promoting an efficient maintenance of the cell. Recently, epigenetic studies have shown that customized lifestyle taking into account both genetic background and lifestyle, are very sensitive to the aging process and can either be a biomarker of the quality of aging or influence the rate and the quality of aging.  Of course, risks such as smoking, obesity, sedentary lifestyle and over-exertion increase our liklihood of having premature accidents.  This third element is difficult to adjust as “the recipe for success is the same recipe for a nervous breakdown!”

Disharmony =  Rapid Aging and Disease

Genetics

Before the 1990ies it was largely believed that aging is preprogrmmed and that genetics does not control it. It was this view, the idea that aging occurs after reproduction that was challenged and proven to be in error.  Later studies  including those of  David Sincalire and Elezibeth Blackburn clearly demonstrated that genetic variability could indeed affect lifespan. This triggered many studies in model organisms in order to disentangle the different biochemical pathways which could affect lifespan, and to highlight the genes coding for the proteins involved in such pathways. on, and then there is no need, but also no opportunity, for selection to act on genes that are expressed during this late period of life.

On the whole, current studies are showing that interventions modulating the interaction between genetic background and environment is essential to determine the individual chance to attain longevity.

Biomarkers – Getting A Personal Roadmap For Health

The successful development and implementation of interventions to promote healthspan will require the use of aging biomarkers. Biomarkers are defined here as biological characteristics that can be objectively measured and evaluated as indicators of age-related normal and pathogenic processes.  These include blood, urine, saliva and stool analysis to evaluate a person’s current condition which allows targeting the optimum.  In practice, such biomarkers  aid in diagnosing individual aging characteristics, predicting the progression of these and selecting possible diet and lifestyle interventions, and evaluating the effects and outcomes of such interventions on a regular/annual basis.

These biomarkers are needed to define the parameters that should be targeted in interventions. A disease can be defined as a disorder or abnormality of structure or function. Health on the other hand is more than just normal lab values but those that produce slow aging and restorative body system characteristics. Some have argued that aging cannot be abnormal because everyone suffers from it, which has led to the reluctance to accept aging as the equivalent of a disease.   This is no longer accepted by those studying health and longevity.  Fasting promoted by early natural physicians is now being closely evaluated for modern health promotion.

Intermittent and prolonged fasting

Dietary restriction in several instances has been observed for over five decades to slow aging.  Fasting is the most extreme of the dietary restriction interventions because it requires the complete elimination of nutrients. The best-characterized form of fasting evaluated in  human studies is intermittent or alternate-day fasting (IF or ADF), which involves the feeding on every other day for long periods of time. Prolonged fasting (PF), in which water but not food is consumed for two or more consecutive days, is also becoming a well-investigated intervention. The mechanisms of action of fasting are best understood in the in the biochemistry where a switch from glucose-containing medium to water causes the downregulation high stress genetic pathways, and the activation of the stress resistance transcription factors which regulate many protective and metabolic genes. These changes, similar to those observed in starved worms and mice, promote resistance to both multiple toxins and longevity extension.

Activators of the sirtuin pathways

The metabolites sirtuins (SIRT1 to 7) promote longevity in many species and could mediate many of the beneficial effects of DR (Satoh et al., ). Given their apparent role in mediating health benefits, sirtuins have attracted considerable interest as a drug target. The first potent sirtuin-activating compounds (STACs) to be identified included several classes of plant-derived metabolites, such as flavones, stilbenes, chalcones, and anthocyanidins. These phytochemicals directly activate SIRT1 in vitrothrough an allosteric mechanism that lowers the metabolic rate of aging. Resveratrol (3,5,4′-trihydroxystilbene) one of the active ingredients in Shaklee Vivix, is still the most potent of these natural activators identified to date. The discovery of natural STACs prompted the production of synthetic SIRT1 activators that are considerably more potent, soluble, and toxic to many users. In many studies, resveratrol and synthetic STACs have been shown to induce physiological and gene expression changes that are similar to DR, and improve function and extend the lifespan of numerous organisms including humans.

Health Risk Assessment/Reduction

Besides these common considerations:

  • Your age. Babies and older adults tend to get sicker quicker.
  • Your overall health. If you have a condition such as diabetesHIVcancer, or heart disease, you may need to pay closer attention to certain symptoms and take control sooner.
  • Medicines you take. Certain prescription medicines, herbal remedies, and the wrong supplements can cause symptoms or make them worse.
  • Recent health events, such as surgery or injury. These kinds of events can cause symptoms afterwards or make them more serious.
  • Your health habits and lifestyle, such as eating and exercise habits, smoking, alcohol or recreational drug use, sexual history, and travel.

you must look at clinical conditions in family members as well.

  • Heart disease and stroke.
  • Childhood obesity.
  • High blood pressure.
  • Diabetes.
  • Some cancers.
  • Gallbladder disease and gallstones.
  • Osteoarthritis.
  • Gout.
  • Breathing problems, such as sleep apnea (when a person stops breathing for short episodes during sleep) and asthma.

Optimizing your health may just require a few more positive activities:

1. Drink more water. Your cells are 70 percent water and you need water for every bodily function.  Many of the aches and pains, headaches, and other symptoms  would lessen if we just drank more water.

2. Go for a brisk interval walk. Your body was made to move and needs physical motion to function optimally. We know this but we often need a reminder to just do it.

3. When possible, take your brisk walk in nature. Trees and other plants are regularly turning our carbon dioxide into rich oxygen we can breathe. Getting rich, oxygenated air help kill bacteria and viruses, improves breathing, and may even help prevent cancer.

4. Hug a loved one. When you hug someone you love (someone who actually wants to be hugged), your body releases feel-good hormones like oxytocin that ward off depression.

5. Eat 2 or 3 pieces or servings of fruit (count ½ cup of fruit like grapes, blueberries, cherries, etc. as a serving). Brilliantly-colored fruit is packed with disease-fighting phytonutrients like proanthocyanins that protect against brain diseases and quercetin which helps alleviate allergies and breathing problems

6. Eat a large salad. I’m frequently told by someone who is making excuses for his/her bad diet that eating healthy is expensive. Nonsense. Some of the best superfoods are cheap and readily available in the form of salad greens. They are packed with vitamins, minerals, chlorophyll (gives plants their green color and boosts our blood health), enzymes (that improve digestion and increase energy), and many phytonutrients.

7. Meditate and Pray. Just taking some time out to clear your thoughts and unplugging from technology and people can help you feel more balanced and peaceful.  Thank God personally for the positives in your life.

8. Deep breathe for at least 5 minutes, as often as you can. Research shows that deep breathing, even for minutes, can reduce stress hormone levels. That translates into less anxiety, better sleep, and less likelihood to pack on the pounds.

9. Snack between meals on healthy snacks like almonds, veggie crudite, hummus and whole grain pitas. Not only will you stabilize your moods, you’ll balance your weight thanks to regulated blood sugar levels.

10. Drink a freshly made juice—preferably with green veggies. Green juices are Mother Nature’s healing nectar. They are powerhouses of nutrients that help your body heal and energize you all at once.

11. Stop and smell the flowers, literally. Not only will slowing down make you feel great, you will be exposed to natural aromatherapy with relaxing, energizing, or therapeutic effects. The fact that you can smell the flowers means molecules of their essential oils are coming into contact with your sensory systems—one of the fastest ways to balance hormones.

12. Write down at least 10 things for which you are thankful.  Increasing amounts of research show that gratitude builds better health and happiness.

13. Eliminate everything in your home that contains toxic chemicals (all commercially-available dryer sheets, almost every type of commercial laundry soap sold in grocery stores, dish soap, “air fresheners,” etc.) For essential items, choose only Shaklee cleaning and houshold products.

14. Do something nice for someone. Stories are becomming more frequent of people practicing random acts of kindness.. When asked for the bill at a restraunt or grocery store it is overwhelming to find out that it had been paid by a gentleman whom we had never met. It not only made our day, we still think back with fondness about this kind man and how it gave us more faith in the goodness of people.

15. Dry skin brush. Dry skin brushing in small circles with a natural bristled brush, working from your extremities toward your heart boosts your blood circulation and the movement of lymph through your body to help eliminate toxic waste buildup in your tissues while boosting your energy.

16. Soak in a warm bath with Epsom salts. The magnesium in Epsom salts absorbs through your skin and helps relax your muscles and reduce pain levels while contributing to your heart health.

[highlight]Try these suggestions and go on our facebook or website and tell us your experience.  I am excited to see how the simple things can bring out the best in our genes and prevent risks from taking their toll on our health.  Best wishes for your future long health!  [/highlight]
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