Gene Disorders – Are They Lifestyle Controlled?

by | Oct 17, 2016

Genetic disorders are  caused by abnormalities in the genetic code  contained within our cells.  Some 4,000 are inherited but many more are possibly the result of poor lifestyle.

Genetic testing for couples helps prevent many disorders.

Genetic testing for couples helps prevent many disorders.

Some of these genetic abnormalities can lead to cancer, while others lead to various health conditions. Genetic disorders may be heritable and passed on from family members or non-heritable and acquired during a person’s lifetime. Acquired genetic disorders refer to conditions caused by acquired mutations in parts of the DNA.  To what extent a person suffers form a genetic condition may be determined to some degree by environmental factors and diet.  Dietary lifestyle choices can alter the negative possibilities of defective genes – this is the new field of nutrigenomics.

Epigenetics Has Transformed The Way We Think About Genomes

Epigenomics is the study of changes in organisms caused by modification of gene expression through diet, exercise, environment and stress rather than alteration of the genetic code itself. Gene expression is like driving your care at different speeds using different gears due to climbing a hill. Choosing the attributes of which genes to use under different conditions is an amazing quality of living matter.  The future of preventive medicine is in identification of “special-needs-genes” and how to support their molecular needs.  Supplementation will be a major tool practitioners will use to meet the unique needs of these genes. Genetic disorders can also be multifactorial inheritance disorders, meaning they are caused by a combination of several mutations and environmental factors. Conditions as common as heart disease and diabetes are now considered to be multifactorial disorders amiable to nutrition and lifestyle changes.

Nutrigenetics and Personalized Nutrition

genetic testingNutrigenetics is the study of the relationships among genes, diet, and health outcomes.1 Nutrigenomics, a related but distinct field, is the study of how genes and nutrients interact at the molecular level. The field of nutrigenetics is relatively new. In 2003, the Human Genome Project, which identified all the genes in human DNA and determined the sequence of the 3 billion chemical base pairs that make up human DNA, was completed. Knowing the sequences of the human genome opened the doors to examine the relationship among an individual’s genetic makeup, dietary intake, and health outcomes.

The excitement surrounding nutrigenetics stems from the notion that it’s the foundation of personalized nutrition. Clearly, population-based dietary recommendations are helpful, but they aren’t adequate for all individuals since people respond differently to diets. Personalized nutrition bases dietary recommendations on genetic predisposition to disease. The idea is that once personalized nutrition is integrated into routine care, patients can be genotyped for specific genetic variations, made aware of their chronic disease risk and nutrient deficiencies, and given strategies to dramatically reduce their risk.

Why Isn’t Nutrigenomic Testing Being Done More?

At present, personalized nutrition isn’t widely practiced since genotyping  it is not reimbursable by insurance due to its lack of cost-effectiveness.  As a result, practitioners do not have experience to go from the lab tests to the kitchen table.  Private companies offer genotyping and personalized nutrition advice based on a handful of genetic variations, but how this is effective in promoting health and preventing chronic disease hasn’t been scientifically determined.  Those of us who have a few years and hundreds of patient profiles using genomic evaluation along with conventional blood, urine, saliva and stool tests have found it an indispensable help in guiding patients to better health.

Human Genes Share 50% Of Banana Genes

Interestingly, the genetic variation among humans is minimal. Most people are approximately 99% genetically identical, with little variation in the roughly 3 billion base pairs that comprise the human genome. However, this approximately 1% genetic variation leads to a wide variability of health outcomes, depending on dietary intake and other environmental exposures.  It makes sense that we are related to our food – that is the general plan of things.  Enzymes, phytohormones and nutrients made by plants become the basic templates for our own fundamental design.  Variations in genes have been a means of adapting to changing conditions around us.  An interesting fact is that Shaklee avoids and protects against GM components (IPP – Identity Preserved Program)in their food supplements due to the possible allergic response and unknown interactions with our own genome.  This fact alone makes Shaklee a premium food supplement and needs to be promoted more in the field.

The excitement surrounding nutrigenetics stems from the notion that it’s the foundation of personalized nutrition. Clearly, population-based “normal” dietary recommendations are helpful, but they aren’t adequate for all individuals since people respond differently to diets. Personalized nutrition bases dietary recommendations on genetic predisposition to disease. The idea is that once personalized nutrition is integrated into routine care, patients can be genotyped for specific genetic variations, made aware of their chronic disease risk and nutrient deficiencies, and given strategies to dramatically reduce their risk.

testingtemomeresPreventive Genomic Testing

Genetic testing enables one to minimize the risk by:

  • Identifying hidden gene mutations that may promote chronic disease
  • Preventing disease through early intervention
  • Modifying gene expression through more precise, targeted, individualized interventions
  • Identifying key areas for follow-up testing
  • Monitoring therapeutic effectiveness of intervention strategies with laboratory testing

Whether or not you choose to see genes, they are always there and will continue to play an important role in one’s health.  With genomic testing, by choosing to look at them, you have the opportunity to influence the ultimate outcome with your diet and supplements and more actively promote a healthy life.

There are currently several different profiles.  These target various organs and systems that are commonly altered in their directing biochemical processes.

  • Detox Genomic Test – This test evaluates SNPs associated with increased risk of impaired detoxification capacity especially especially the liver when exposed to metabolic or environmental toxins.  It also identifies individuals potentially susceptible to adverse drug reactions.
  • Immuno Genomic Test -This test evaluates genetic variations in genes that modulate immune and inflammatory activity. These variations can affect balance between cell (Th-1) and humoral (Th-2) immunity, trigger potential defects in immune system defense, and stimulate mechanisms underlying chronic, overactive inflammatory responses.   This is a very useful tool for assessing cancer susceptibility and prognosis.
  • Neuro Genomic Test -This test evaluates single nucleotide polymorphisms (SNPs) in genes that modulate methylation, glutathione conjugation, oxidative protection and the potential to evaluate vascular oxidation within the nervous system.  It is especially helpful in people with sleep, learning, behavioral and seizure disorders.
  • Cardio Genomic Test – This profile analyzes blood and utilizes NMR fractionation technology for state-of-the-art lipid markers and independent risk factors that illuminate the clinical complexity of cardiovascular disease (CVD) as well as a patient’s genomic predisposition to cardiovascular diseases. Together, these markers provide a thorough assessment of cardiovascular health status, revealing the biochemical environment and cardiogenomic risk associated with inflammation, lipid deposits, endothelial dysfunction, and clotting factors underlying cardiovascular disease.
  • A most frequently requested test is the EstroGenomic® Profile uses genomic testing to identify susceptibility to diseases and conditions such as breast cancer, osteoporosis, and heart disease. More specifically, the EstroGenomic® Profile evaluates genetic variations, called single nucleotide polymorphisms (SNPs) in genes that modulate estrogen metabolism, coagulation, cardiovascular function, bone health, and inflammation.

The EstroGenomic® profile uncovers potential genetic susceptibility to diseases and conditions such as:

  • Breast cancer
  • Osteoporosis
  • Thrombosis
  • Strokes
  • Atherosclerosis
  • Heart Disease

Genetic testing enables one to minimize the risk by:

  • Identifying hidden gene mutations that may promote chronic disease
  • Preventing disease through early intervention
  • Modifying gene expression through more precise, targeted, individualized interventions
  • Identifying key areas for follow-up testing
  • Monitoring therapeutic effectiveness of intervention strategies with laboratory testing

Whether or not you choose to see genes, they are always there and will continue to play an important role in one’s health.  With genomic testing, by choosing to look at them, you have the opportunity to influence the ultimate outcome and more actively promote a healthy life. The EstroGenomic® Profile evaluations include:

Estrogen Metabolism

  • CYP1A1
  • GST (M1 and P1)
  • CYP1B1
  • COMT (catechol-O-methyl transferase)

Estrogen metabolism SNPs focus on the Phase 1 enzymes involved in the formation of anti- or procarcinogenic metabolites such as 2-hydroxyestrone and 4-hydroxyestrone, respectively, as well as the Phase 2 enzymes responsible for the subsequent metabolism of these compounds. Levels of the various estrogen metabolites modulate risk of both breast cancer and osteoporosis.

HyperCoagulation

  • GP3a (Glycoprotein 3)
  • Factor 2 (Prothrombin)
  • PAI-1 (Plasminogen activator inhibitor-1)
  • Factor 5 (Leiden)

These genetic variants focus on estrogens interaction with some of the key constituents of the clot formation and fibrinolysis process, such as clotting factors and inhibitors of fibrinolysis. The SNPs can over-activate blood clotting processes, increasing the risk of sudden cardiac events such as thrombosis, heart attacks, and strokes, especially among women take supplemental estrogens and oral contraceptives.

Cardiovascular

  • Apo E (apoliprotein E)
  • TNF-a
  • MTHFR
  • IL-6

These genes affect how the body processes cholesterol, responds to inflammation, and metabolizes B vitamins. The presence of these SNPs can increase risk of cardiovascular disease, hyperlipidemia, and blood vessel damage.

Osteoporosis

  • VDR
  • TNF-a
  • IL-6

Osteoporosis SNPs relate to estrogens influence on inflammation, bone resorption, vitamin D function and bone collagen formation.

To Get Your Own Personalized Nutritional Analysis Report & CD through the Build A Better You Program. Call Angie: (503) 631-4184
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